A Novel Drug-Drug Salt of Naproxen and Vortioxetine: Synthesis, Characterization, and Solubility Study

Naproxen (NAP) is an aromatic propionic acid nonsteroidal anti-inflammatory drug, and vortioxetine (VOT) a novel antidepressant drug. In this study, new 1 : drug-drug salt of NAP VOT (namely, NAP-VOT) was designed synthesized by liquid-assisted grinding slow evaporation. The obtained characterized single-crystal X-ray diffraction, powder diffraction (PXRD), differential scanning calorimetry (DSC). Single-crystal structure showed that NAP-VOT molecular salt. molecules in the were connected N-H+⋯O hydrogen bonds between carbonyl oxygen piperazine group VOT. addition, solubility dissolution rate experiments performed water pH 6.86 phosphate buffers, result suggested formation could increase water. Furthermore, study provides research idea to solve problem combination achieving association at level.